I think this is actually a pretty good question.
But as an individual with a somewhat limited tolerance for the human race, i answer with a large grain of salt proffered to the reader.
I think we all (and most people in general) have times in our lives when we have had enough of the people around us, be they nearer or more distant to us. We all have times when we seek solitude and quiet contemplation. There are times when we seek out novelty and stimulation and potential conflict. Staring the ugliness of our life in the face and seeing it for what it truely is, while all those about you blithely cling to their delusions, only accentuates the downside when it comes around.
I think we need to listen to our minds, as we listen to our bodies. Just as we listen to our cravings to tell us what nutrients we are lacking, and when we are dehydrated, and when we need stress that needs to be released, etc... So we need to listen to our own minds, and accept when it asks for peace, and when it asks for turmoil, and when it asks to be set free (for awhile).
Personally, i prefer the company of weeds and worms, flowers and bees, trees and birds; they tolerate my company, and accept my words with no ill feeling. I treat people as i would any other dumb animal, with kindness where i can, with brevity and my safety where i can't.