its really a question of perspective and what you value in the world. Is the 'big picture' really that important to you?- all of those things that are totally out of your control? People experience time on a 'human' scale - mornings, afternoons, nights, instants, days, seasons, years, etc. but not really on the scale of universes unfolding. So the question i think is 'do you value your own life?' and really only you can answer that question. The anxiety of the big picture really only makes sense to me if your life is not worth living - the existential idea is really just your actual lived experience projected forwards (mostly) and backwards in time. so if its meaningless in 'real time', its usually looks meaningless in 'universal time'.
Theres probably also something to say about how this type of existential crisis and measuring on such inhuman scales is produced in no less so by the massifying ethos of our time - to think of everything in terms of intangible elements (populations, nation-states, identities, etc.), but i cant say much more on that right now